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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 2, 219-226, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

CHANGES IN RABBIT CORE TEMPERATURE ACCOMPANYING ALTERATIONS IN BRAINSTEM MONOAMINE CONCENTRATIONS

M. K. Shellenberger 1 and J. T. Elder 1

1 Department of Pharmacology, University of Washington, Seattle, Washington

The endogenous stores of norepinephrine, dopamine and 5-hydroxytryptamine in the rabbit brainstem have been manipulated through the use of agr-methyl-m-tyrosine, reserpine and pargyline. The changes in amine levels were estimated by fluorometric assay. The rabbits’ core temperatures were monitored during drug treatment and it was found that increases in temperature were correlated with increases in 5-hydroxytryptamine and dopamine while norepinephrine was implicated as an antagonist of temperature increases. Feldberg and Meyers have proposed that temperature regulation results from a balance between the hyperthermic effects of 5-hydroxytryptamine and the hypothermic effects of norepinephrine in the hypothalamus. The experiments reported here support this hypothesis.

Submitted on September 19, 1966
Accepted on July 5, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.