JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neff, N. H.
Right arrow Articles by Brodie, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neff, N. H.
Right arrow Articles by Brodie, B. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 2, 214-218, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

APPLICATION OF STEADY-STATE KINETICS TO STUDIES OF THE TRANSFER OF 5-HYDROXYINDOLEACETIC ACID FROM BRAIN TO PLASMA

Norton H. Neff 1, Thomas N. Tozer 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Probenecid, a drug that competitively inhibits the renal tubular secretion of a number of acidic substances, also blocks the efflux of 5-hy-droxyindoleacetic acid (5-HIAA) from rat brain. The rate at which 5-HIAA is accumulated after probenecid administration almost exactly equals the rate of formation of this acid from serotonin (5-HT). These results imply that 5-HIAA and perhaps other acidic products of brain metabolism are transferred directly from brain to plasma by a specialized process.

Submitted on March 27, 1967
Accepted on June 13, 1967




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
G. Lee, S. Dallas, M. Hong, and R. Bendayan
Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations
Pharmacol. Rev., December 1, 2001; 53(4): 569 - 596.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. B. Pritchard, D. H. Sweet, D. S. Miller, and R. Walden
Mechanism of Organic Anion Transport across the Apical Membrane of Choroid Plexus
J. Biol. Chem., November 19, 1999; 274(47): 33382 - 33387.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Koslow and I. Butler
Biogenic amine synthesis defect in dihydropteridine reductase deficiency
Science, November 4, 1977; 198(4316): 522 - 523.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Post and F. Goodwin
Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients
Science, October 31, 1975; 190(4213): 488 - 489.
[Abstract] [PDF]

Home page
 ScienceHome page
R. J. Hitzemann, I. K. Ho, H. H. Loh, D. L. Cheney, and E. Costa
Narcotic Tolerance and Dependence and Serotonin Turnover
Science, November 10, 1972; 178(4061): 645 - 647.
[PDF]

Home page
 ScienceHome page
M. Bulat and B. Zcaronivkovicacute
Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid
Science, August 20, 1971; 173(3998): 738 - 740.
[Abstract] [PDF]

Home page
 ScienceHome page
R. C. Lin, S. H. Ngai, and E. Costa
Lysergic Acid Diethylamide: Role in Conversion of Plasma Tryptophan to Brain Serotonin (5-Hydroxytryptamine)
Science, October 10, 1969; 166(3902): 237 - 239.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.