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*(L)-TRYPTOPHAN
*5-HYDROXYTRYPTOPHAN
*DACTINOMYCIN
Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 2, 206-213, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

CIRCADIAN RHYTHM IN THE SEROTONIN CONTENT OF THE RAT PINEAL GLAND: REGULATING FACTORS

Solomon H. Snyder 1, Julius Axelrod 1, and Mark Zweig 1

1 Laboratory of Clinical Science, National Institute of Mental Health. Bethesda, Maryland

There is a marked circadian rhythm in the serotonin content of the rat pineal gland. The rhythm can be inverted 180° by reversal of the lighting regimen. Phase inversion is complete in 6 days. The activities of 5-hydroxytryptophan decarboxylase and monoamine oxidase in the pineal gland do not exhibit a circadian variation. The absolute increase in pineal gland serotonin produced by tryptophan or 5-hydroxytryptophan injection is much greater than in other tissues but does not vary at different times of day and night. Treatment with beta-phenylisopropyhlmydrazine, a monoamine oxidase inhibitor, prevents the nocturnal decline of pineal serotonin but does not alter daytime levels. Treatment with actinomycin D partially inhibits time daytime increase in pineal serotonin.

Submitted on May 29, 1967
Accepted on July 7, 1967




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