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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 1, 99-114, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

THE RATE OF ACTION OF COMPETITIVE NEUROMUSCULAR BLOCKING AGENTS

D. R. Waud 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Tubocurarine, dimethyltubocurarine, gallamine and n-C10H21NMe3 have been applied iontophoretically to the end-plate region of frog skeletal muscle fibers. The rate of action of these drugs has been measured by testing the endplate with iontophoretically-applied doses of carbachol. All drugs used act rapidly and behave as if access to the receptor is rate-limiting. Thus no experimental support was obtained for a kinetic model of drug action.

Submitted on March 13, 1967
Accepted on May 3, 1967






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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.