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Journal of Pharmacology And Experimental Therapeutics, Vol. 158, Issue 1, 164-173, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION OF THIOPENTAL-2-C14 IN MATERNAL AND FETAL TISSUES OF THE RAT

Paul J. Schechter 1 and Lloyd J. Roth 1

1 Department of Pharmacology, The University of Chicago, Chicago, Illinois

Radioactivity in various maternal and fetal tissues of 21-day-pregnant rats following maternal i.v. injection of C14-thiopental has been measured and whole-body autoradiograms of these pregnant animals have been prepared. The placenta acts as a relative barrier to protect the fetus from the high maternal plasma concentration of thiopental which is anesthetic to the mother. Maternal blood levels of thiopental fall rapidly as the drug enters maternal tissue. The delay imposed by the placenta during the period of falling maternal plasma levels results in a lower fetal plasma concentration than that presented to the maternal central nervous system during the first few minutes following injection. Only unchanged thiopental-2-C14 has been found in methylene chloride extracts of the maternal and fetal tissues assayed.

Submitted on October 6, 1966
Accepted on May 10, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.