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1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland
The uptake and metabolism of H3-norepinephrine and the endogenous content of norepinephrine were examined in the heart, spleen, salivary glands and intestine of developing rats. There were differences in the relative concentrations of endogenous norepinephrine in various tissues at birth, the heart having the lowest level and the intestine the highest level. These differences were also evident in the rate at which the adult level of norepinephrine was attained in the various tissues. In the heart and spleen, the ability to accumulate H3-norepinephrine developed parallel to the endogenous norepinephrine content. In contrast, the ability of the intestine and salivary gland to accumulate H3-norepinephrine was already fully developed at birth, although these tissues lacked a normal norepinephrine content at this time. The subcellular distribution of H3-norepinephrine and the extent of depletion of the labeled amine by tyramine or reserpine were similar in the immature and adult rat heart. However, the accumulated amine disappeared more rapidly from the immature heart than from the adult heart. Chronic treatment of newborn animals with cortisone, thyroxin or reserpine or the rearing of animals under unfavorable nutritional circumstances resulted in an impairment in the capacity of the heart to accumulate H3-norepinephrine. The rearing of animals under optimal growth conditions caused an accelerated growth of myocardial tissues, but did not affect the rate of development of norepinephrine uptake sites in the heart.
Submitted on March 6, 1967
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