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Journal of Pharmacology And Experimental Therapeutics, Vol. 157, Issue 2, 432-434, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

PROPHYLAXIS AGAINST SARIN POISONING IN THE RAT BY ORAL ADMINISTRATION OF PRALIDOXIME CHLORIDE

Peter Zvirblis 1 and Albert A. Kondritzer 1

1 Physiological Chemistry Branch, Medical Research Laboratory, Edgewood Arsenal, Maryland

Pralidoxime chloride (2-PAM Cl) has been given orally to rats and the concentration of oxime in time blood plasma as well as time rate of elimination has been established. On the basis of a disappearance rate that approximated first-order kinetics the biologic half-life of the drug was estimated to be 1.4 hr. The prior administration of 2-PAM Cl to rats also treated with atropine resulted in significant decreases in the toxicity of sarin. These findings could be correlated with the concentration of oxime in the plasma at the time the toxicant was injected. The use in man of pralidoxime chloride in conjunction with atropine for the prophylaxis of poisoning by organophosphonis chemicals is suggested.

Submitted on February 10, 1967
Accepted on March 17, 1967




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