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Journal of Pharmacology And Experimental Therapeutics, Vol. 157, Issue 2, 303-310, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

AUTOINHIBITION IN RABBIT AORTIC STRIPS AFTER EPINEPHRINE

Efraín G. Pardo 1, Enrique Hong 1, and Jacques Lelorier 1

1 Instituto Miles de Terapéutica Experimental, Mexico, D. F., México

Experiments have been carried out to characterize further the autoinhibitory phenomenon which follows contact of rabbit aortic strips with epinephrine. Desensitization was found to occur after exposure to very low concentrations of the catecholamines. The time course of recovery from inhibitory contacts with different concentrations of epinephrine was such as to predict that autoinhibition would generally he a significant factor in modifying experimental determinations of dose-response relationships. This was found to be the case, and a graphical method, leading to drug-effect hysteresis loops, is proposed as a means of assessing the degree of participation of this factor in a given experimental situation.

Submitted on January 3, 1966
Accepted on March 21, 1967






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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.