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Journal of Pharmacology And Experimental Therapeutics, Vol. 157, Issue 1, 96-102, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DISULFIRAM ON CATECHOLAMINE LEVELS IN THE BRAIN

Menek Goldstein 1 and Kazuhiko Nakajima 1

1 Department of Psychiatry and Neurology, Neurochemistry Laboratory, New York University School of Medicine, New York, New York

Disulfiram, a potent inhibitor of dopamine-beta-hydroxylase, is effective in lowering endogenous norepinephrine and in elevating endogenous dopamine in the norepinephrine-containing regions of the brain. The decrease in the norepinephrine content exceeded the increase in the dopamine content in all analyzed regions of the brain. In animals pretreated with the monoamine oxidase inhibitor pheniprazine, there was a closer correlation between the decrease in the norepinephrine content and the increase in the dopamine content in the hypothalamus and brainstem. Disulfiram also inhibits the replenishment of brain norepinephrine stores after depletion by oxypertine or reserpine. agr-Methyl-L-tyrosine, an inhibitor of tyrosine hydroxylase, and disulfiram, an inhibitor of dopamine-beta-hydroxylase, were compared with respect to the lowering of norepinephrine in the brain. Two hours after administration of the inhibitors, disulfiram was more effective in lowering the norepinephrine levels than agr-methyl-L-tyrosine.

Submitted on May 13, 1966
Accepted on January 25, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.