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Journal of Pharmacology And Experimental Therapeutics, Vol. 157, Issue 1, 214-219, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

INDUCTION OF PERIARTHRITIS BY ORAL ADMINISTRATION OF 6-SULFANILAMIDOINDAZOLE AND ITS TREATMENT IN RATS

E. B. Sigg 1, M. L. Graeme 1, and M. John 1

1 Geigy Research, Division of Geigy Chemical Corporation, Ardsley, New York

In rats, 10 to 13 months old, 6-sulfanilamidoindazole produces a chronic periarthritis which differs from that induced by mycobacterial adjuvant in regard to etiology, symptomatology and therapeutic susceptibility. Simultaneous administration of nonsteroidal and steroidal antiinflammatory agents suppress the periarthritis induced by 6-sulfanilamidoindazole. Immunosuppressive agents are ineffective.

Submitted on October 19, 1966
Accepted on December 13, 1966






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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.