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Journal of Pharmacology And Experimental Therapeutics, Vol. 157, Issue 1, 175-184, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

SOME EFFECTS OF MORPHINE AND MORPHINE ANTAGONISTS ON SCHEDULE-CONTROLLED BEHAVIOR

D. E. McMillan 1 and W. H. Morse 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

The effects of morphine, nalorphine and two benzomorphan narcotic antagonists were studied under a multiple fixed-ratio, fixed-interval schedule of food presentation. At appropriate doses all of the drugs increased rate of responding under the fixed-interval component. Higher doses decreased responding under both the fixed-interval and fixed-ratio components. The rank order of potency was the same for both the rate-increasing the rate-decreasing effects, with cyclazocine being the most potent, then morphine, pentazocine and nalorphine. The effects obtained after weekly injections of morphine could be replicated, suggesting that effects of tolerance were minimal. After daily administrations of morphine, however, higher doses decreased responding less, but the same qualitative effects were still observed.

Submitted on July 19, 1966
Accepted on February 7, 1967




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.