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Journal of Pharmacology And Experimental Therapeutics, Vol. 156, Issue 3, 591-597, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

AN EFFECT OF DIPHENYLHYDANTOIN ON POSTTETANIC HYPERPOLARIZATION OF INTRAMEDULLARY NERVE TERMINALS

Arthur Raines 1 and Frank G. Standaert 1

1 Department of Pharmacology, Cornell University Medical College, New York, New York

Diphenythydantoin (DPH), in anticonvulsant doses, abolishes posttetanic hyperpolarization originating in the central terminals of dorsal root fibers of spinal cats. Depression of posttetanic hyperpolarization by DPH probably accounts for the drug's reduction of posttetanic potentiation in the monosynaptic reflex and repetitive afterdischarges originating in nerve terminal structures. Since the latter two phenomena have been implicated as possible seizure mechanisms, depression of posttetanic hyperpolarization may be a more fundamental anticonvulsant property.

Submitted on September 16, 1966
Accepted on December 15, 1966






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