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Journal of Pharmacology And Experimental Therapeutics, Vol. 156, Issue 2, 331-338, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE ANTIARRHYTHMIC ACTIONS OF TWO NEW SYNTHETIC COMPOUNDS, IPROVERATRIL AND MJ 1999, WITH QUINIDINE AND PRONETHALOL

Jack R. Schmid 1 and Calvin Hanna 1

1 Pharmacology Department, University of Arkansas Medical Center, Little Rock, Arkansas

The antiarrhythmic actions of MJ 1999 (4-(2-iso-propylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride) and iproveratril were compared with the reference drugs quinidine and pronethalol against four types of experimentally-induced cardiac arrhythmias in dogs. Quinidine was consistently the most effective of the four compounds tested, suppressing 89% of all arrhythmias treated. Iproveratril in very small doses was effective against all four types of experimentally-induced arrhythmias, especially against the ventricular arrhythmias induced by hydrocarbonepinephrine and ouabain. The range of its potency on a micrograms per kilogram basis was from approximately twice that of quinidine and pronethalol against aconitine-induced atrial arrhythmias to about 30 times that of quinidine and pronethalol vs. coronary artery ligation-induced ventricular arrhythmias. The beta-adrenergic receptor blocking compound MJ 1999 was not effective in suppressing ouabain-induced tachycardia, but it was effective in suppressing aconitine- and coronary artery ligation-induced arrhythmias. MJ 1999 was highly effective in blocking hydrocarbon-epinephrine-induced arrhythmias at a dose that was in the range of its beta-adrenergic receptor blocking dose. MJ 1999 had an antiarrhythmic potency approximately twice that of pronethalol against all arrhythmias except ouabain-induced tachycardia.

Submitted on September 6, 1966




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