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Journal of Pharmacology And Experimental Therapeutics, Vol. 156, Issue 2, 267-276, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

RELEASE OF INTESTINAL 5-HYDROXYTRYPTAMINE BY MORPHINE AND RELATED AGENTS

T. F. Burks 1 and J. P. Long 1

1 Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa

Release of 5-hydroxytryptamine (5-HT) into the perfused vasculature of isolated dog intestinal segments has been found to occur after intraarterial administration of morphine, meperidine, levorphanol, methadone, nalorphine, codeine or apomorphine. The duration of 5-HT release approximately corresponded with the increased intestinal tone produced. Morphine and codeine were shown to be less potent spasmogens of dog intestine during periods of 5-HT tachyphylaxis than during control periods. Perfusion of isolated dog intestinal segments with calcium iondeficient solutions reversibly decreased intestinal responses to morphine, codeine, levorphanol, 5-HT, nicotine and acetylcholine. Potassium ion deficiency had no significant effects. The in situ intestinal responses to morphine were decreased in reserpine-pretreated dogs. It is suggested that 5-HT participates in dog intestine responses to morphine and related agents.

Submitted on August 15, 1966
Accepted on November 14, 1966




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.