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1 Departments of Psychiatry and Anatomy, Yale University School of Medicine, New Haven, Connecticut
Tritiated serotonin (H3-5HT) was given by intraventricular injection and its localization in brain was studied by light-and electron-microscopic autoradiography. Furthermore, an attempt was made to evaluate the chemical and structural specificity of localization by comparing sites of uptake of H3-5HT with those of tritiated norepinephrine (H3-NE). Among the paraventricular regions examined (caudate nucleus, septum, amygdala, hypothalamus and midbrain central gray), the central gray was found to have the most intense autoradiographic activity after intraventricular H3-5HT. The activity in the central gray (and other regions) was predominantly localized in nerve endings and unmyelinated axons. Nerve endings with activity usually contained dense-core vesicles as well. In comparison to the central gray, the paraventricular nucleus of the hypothalamus had little activity after H3-5HT. The reverse was found to be the case for H3-NE. Since endogenous 5-HT is very high in the central gray and low in the paraventricular nucleus of the hypothalamus, the results suggest that the localization of intraventricularly injected H3-5HT is correlated with the presence of endogenous 5-HT and not NE. However, no distinction on purely morphologic grounds could be made between endings taking up H3-5HT or H3-NE.
Submitted on August 4, 1966
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