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Journal of Pharmacology And Experimental Therapeutics, Vol. 156, Issue 1, 186-192, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF DOPAMINE ON RENAL FUNCTION AND HEMODYNAMICS IN THE DOG

M. B. Meyer 1, John L. McNay 1, and Leon I. Goldberg 1

1 Departments of Pharmacology and Internal Medicine (Section of Clinical Pharmacology), Emory University School of Medicine, Atlanta, Georgia

In waterloaded dogs, both conscious and anesthetized, the continuous infusion of 6 µg/kg/min of dopamine produced an increase in sodium, potassium and oSmolal excretion. Clearances of p-aminohippurate (CPAH) and inulin also increased during dopamine infusion. In a separate series of experiments, the extraction of PAH decreased during dopamine administration. In a third series, infusions of 0.6 or 1.2 ,µg/kg/min of dopamine into the left renal artery produced ipsilateral changes in urine formation comparable to those seen with intravenous infusion and greater than those observed on the contralateral side. CPAH increased significantly more on the infused side than on the contralateral side, but increases in the clearance of inulin were bilaterally equal. It was concluded that the changes in urine formation in the dog resembled those previously observed in man and were not dependent upon systemic hemodynamic changes.

Submitted on August 29, 1966
Accepted on October 4, 1966




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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.