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Journal of Pharmacology And Experimental Therapeutics, Vol. 155, Issue 2, 318-329, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC FATE OF beta-(3,4-DIMETHOXYPHENYL)-ETHYLAMINE IN MAN

K. D. Charalampous 1 and L. Wayne Tansey 1

1 Department of Psychiatry, Baylor University College of Medicine, and Houston State Psychiatric Institute, Houston, Texas

The metabolism of C14-labeled beta-(3,4-dimethoxyphenyl)ethylamine (DMPEA), reported to be present in the urine of several patients with mental disorders, was studied in man after oral administration. The cumulative excretion of radioactivity in the urine and the concentration of the radioactive material in plasma and cerebrospinal fluid were determined. Unchanged DMPEA, 3,4-dimethoxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid were identified and their concentration determined in the collected urine. The rate of deamination of ingested DMPEA was twice that of mescaline. Aspects of the metabolic fate of mescaline and DMPEA were compared with each other and with those of some of their urinary metabolites.

Submitted on June 10, 1966
Accepted on September 14, 1966




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L. Vacca, M. Fujimori, S. H. Davis, and A. S. Marrazzi
Cerebral Synaptic Transmission and Behavioral Effects of Dimethoxyphenylethylamine: A Potential Psychotogen
Science, April 5, 1968; 160(3823): 95 - 96.
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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.