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Journal of Pharmacology And Experimental Therapeutics, Vol. 155, Issue 2, 267-270, 1967
Copyright © 1967 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DIPHENYLHYDANTOIN UPON BEATING OF HEART CELLS GROWN IN VITRO

Edward N. Mercer 1, Wfilliam G. Ziegler 1, Gail F. Wickland 1, and Gordon E. Dower 1

1 Department of Pharmacology, University of British Columbia, Vancouver, Canada

The mechanism by which diphenylhydantoin (DPH) exerts an antiarrhythmic effect in clinical arrhythmias has not been established. In our previous work, digoxin has been demonstrated to induce abnormal contractions-cellular arrhythamis- in discrete cultivated heart cells. The present study was undertaken to examine the effect of DPH upon beating in untreated and in digoxin-treated discrete heart cells. Chick embryo heart cells dissociated by trypsin were grown in vitro and beating was qualitatively and quantitatively studied during the first 48 hr of growth. DPH did not exert a corrective effect upon digoxin-induced cellular arrhythmias, but it caused a reduction in the total percentage of cells beating when used in concentrations of 50 µg/ml or higher. Digoxin effectively antagonized the depressant action of DPH. The results suggested that the antyarrhythmic effect of DPH might be due to direct depression of automaticity of heart cells.

Submitted on July 18, 1966
Accepted on September 6, 1966






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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics.