THE CARDIOPULMONARY EFFECTS OF A QUINAZOLINE (MJ 1988): CARDIAC STIMULANT, PULMONARY VASODILATOR AND BRONCHODILATOR

¹ Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Compound MJ 1988 improved the cardiac performance in a dog heart-lung preparation. In the intact dog, as well as in the heart-lung preparation, the stimulant action on the force of myocardial contraction was accompanied by increases in coronary blood flow, pulmonary vasodilatation and bronchodilatation. Administration of larger doses caused depression of cardiac function and initiated cardiac arrhythmias. The wide margin of safety between the dose that induced the desired action on the heart and the dose that induced the undesired action warrants additional attention to this compound for possible use in the treatment of cor pulmonale complicating acute and chronic lung disease.