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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 3, 652-659, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

FAILURE TO ANESTHETIZE HUMAN SUBJECTS BY INTRAVENOUS ADMINISTRATION OF MAGNESIUM SULFATE

G. Somjen 1, M. Hilmy 1, and C. R. Stephen 1

1 Department of Physiology and Pharmacology and Division of Anesthesiology, Duke University Medical Center, Durham, North Carolina

Two human subjects were given MgSO4 by slow intravenous infusion. The concentration of Mg rose to 15.3 and 14.6 mEq/liter of plasma, from a control value of 1.4 mEq/liter. Profound paralysis of skeletal muscles was produced, with the exception of the diaphragm, the adductors of the vocal cords and some of the facial muscles. The electrocardiogram showed slowing of atrioventricular conduction and alterations of the ventricular action potential. Both subjects remained aware of the surrounding, and in rational contact with the observers. Pain was keenly felt; vision and hearing were normal. Eye centering and conjugate eye movements did not fail. Nystagmus could be provoked in one subject. The electroencephalogram showed diminished agr rhythm and decreased voltage, but none of the common signs of sleep, coma or anesthesia. One of the subjects had amnesia over a short period of time coincident with the occurrence of cyanosis. The other subjects, whose ventilation remained adequate, could remember every detail of the experiment. It is concluded that general anesthesia, or analgesia, cannot be produced by parenteral administration of magnesium. It is doubtful whether in these two experiments any depression of the central nervous system was produced at all by the drug.

Submitted on June 17, 1966
Accepted on July 26, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.