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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 2, 357-363, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF ETHOPABATE IN CHICKENS

Rudolf P. Buhs 1, Donald Polin 1, John O. Beattie 1, John L. Beck 1, Jack L. Smith 1, Otto C. Speth 1, and Nelson R. Trenner 1

1 Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc., and Merck Institute for Therapeutic Research, Rahway, New Jersey

The metabolism by the chicken of orally ingested ethopaabate has been studied, and over 98% of the drug consumed has been accounted for in the urine. Of the urinary excreted drug, about 80 to 85%, on the average, has been isolated and identified as the following metabolites: 20% as 2-ethoxy-4-acetamidobenzoic acid, 15% as 2-ethoxy-4-aminobenzoic acid, 25% as 2-ethoxy-4-amino-5-hythoxybenzoic acid-5-O-sulfate and about 25% as two individual fractions consisting of unidentified conjugates of one or the other of the above first two metabolites. All but the 5-hydroxylated metabolite and about 10% of unknown products are convertible to m-phenetidine, which is the basis of the convenient assay for ethopabate in biologic media.

Submitted on December 28, 1965
Accepted on May 23, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.