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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 2, 350-356, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF MECAMYLAMINE ON AVOIDANCE CONDITIONING AND MAZE LEARNING OF MICE

Alberto Oliverio 1

1 Department of Pharmacology, School of Medicine, University of California, Los Angeles, California

The effects of mecamylamine On avoidance conditioning and maze learning have been studied in DBA inbred mice. At doses ranging from 1.2 to 5.0 mg/kg, mecamylamine strikingly impairs both the acquisition of conditioning and maze learning. The facilitation exerted by nicotine on avoidance learning is reciprocally antagonized by mecamylamine. Trimethidinium, a quaternary ganglionic blocking agent, does not affect learning processes and does not interfere with the action of nicotine. The results are discussed on the basis of the mechanisms of cholinergic transmission.

Submitted on February 25, 1966
Accepted on May 31, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.