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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 2, 298-302, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF DIMETHYL SULFOXIDE ON PERMEABILITY AND ELECTRICAL PROPERTIES OF FROG SKIN

William D. Morain 1, Carol A. Replogle 1, and Peter F. Curran 1

1 Biophysical Laboratory, Harvard Medical School, Boston, Massachusetts

Dimethyl sulfoxide (DMSO) added to the external bathing solution of isolated frog skin causes a decrease in electrical potential difference and an increase in conductance but little change in short-circuit current. The permeability of the skin to mannitol, urea, sodium, potassium and chloride is increased by DMSO but the rate of net active Na transport is not changed markedly. The effects appear to be mainly the result of changes in osmotic activity of the bathing solution since they are similar to the effects caused by urea in similar concentrations.

Submitted on April 13, 1966
Accepted on May 24, 1966






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