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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 1, 103-109, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

RADIOMETRIC MEASUREMENT OF PAW TEMPERATURE CHANGES ASSOCIATED WITH LOCAL INFLAMMATION

Anthony W. Pircio 1 and Edward J. Groskinsky 1

1 Department of Pharmacology, Research Division, Bristol-Meyers Products, Hillside, New Jersey

A radiometric method for measuring the paw temperature of unanesthetized rats is described. It is a simple and accurate means for measuring the paw temperature changes during experimental pedal inflammation induced by the subplantar injection of phlogistic agents. The method may be used as a supplement to other methods for the evaluation of the antiinflammatory activity of drugs. The paw temperature profile resulting from the subplantar injection of yeast shows two peaks, an initial rise followed by a more pronounced rise. Aspirin partially inhibits the initial temperature rise, and greatly suppresses the second. Chlorprophenpyridamine maleate is more effective than aspirin in suppressing the initial temperature rise, but has less inhibitory effect on the delayed response.

Submitted on March 24, 1966
Accepted on April 25, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.