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Journal of Pharmacology And Experimental Therapeutics, Vol. 154, Issue 1, 1-13, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE ACTIONS OF THE CATECHOLAMINES ON TRANSMISSION IN THE SUPERIOR CERVICAL GANGLION OF THE CAT

William C. De Groat 1 and Robert L. Volle 1

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

An elecrotphysiologic study was made of the effects of norepinephrine (NE), epinephrine (E) and isoproterenol (ISO) on transmission in the superior cervical ganglion of the cat. NE produced ganglionic hyperpolarization and blocked ganglionic transmission. These actions were blocked by dihydroergotamine (DHET), and enhanced by dichloroiso-proterenol (DCI) and pronethalol. After the administration of DHET, NE produced ganglionic depolarization and enhanced transmission. These actions were blocked by DCI and pronethalol. Although the actions of E on ganglionic transmission were similar to those of NE, differences were noted between the ganglionic potentials evoked by three amines. For example, although both agents evoked ganglionic hyperpolarization, the E-induced hyper-polarization was followed in many experiments by a phase of depolarization. This depolarization evoked by E was blocked by DCI and pronethalol. ISO produced a depolarization of the ganglion and enhanced transmission. These actions of ISO were blocked by the beta adrenergic blocking agents, but were unaffected by DHET. The above findings indicate that sympathetic ganglia contain two pharmacologically distinctive adrenoceptive sites. It is considered that one site, which was blocked by alpha adrenergic blocking agents, mediated catecholamine-induced inhibition and ganglionic hyperpolarization and that the other site, which was blocked by beta adrenergic blocking agents, mediated catecholamine-evoked facilitation and ganglionic depolarization.

Submitted on March 21, 1961
Accepted on April 25, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.