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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 3, 562-568, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF HYDRAZINE ON LIVER GLYCOGEN, ARTERIAL GLUCOSE, LACTATE, PYRUVATE AND ACID-BASE BALANCE IN THE ANESTHETIZED DOG

SIDNEY R. FORTNEY 1

1 Physiological Chemistry Section, United States Air Force School of Aerospace Medicine, Brooks Air Force Base, Texas

The effects of intravenously injected hydrazine (25-100 mg/kg) on liver glycogen, arterial glucose, lactate and pyruvate were studied in the anesthetized dog. Immediately following hydrazine there was a transient hyperglycemia, followed by a severe hypoglycemia. The response of glucose was dependent on the initial liver glycogen content. Arterial lactate and pyruvate showed marked elevations after hydrazine. Acidosis with "excess lactate" developed several hours later. The rate of lactate and pyruvate accumulation after hydrazine was proportional to hydrazine dosage up to 50 mg/kg. When hypoglycemia was prevented by glucose infusion, glycogen depletion still occurred and lactate and pyruvate accumulation was marked. These effects of hydrazine on glucose metabolism are discussed in the light of other known hydrazine-induced metabolic changes.

Submitted on February 10, 1966
Accepted on March 30, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.