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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 2, 381-385, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF OXYGEN ON CYANIDE INTOXICATION I. PROPHYLACTIC PROTECTION

James L. Way 1, Stanley L. Gibbon 2, and Maureen Sheehy 2

1 Department of Pharmacology, Marquette University, School of Medicine, Milwaukee, Wisconsin
2 Department of Pharmacology, Marquette University, School of Medicine, Milwaukee, Wisconcin

Prophylactic protection against cyanide intoxication in mice can be enhanced by the administration of oxygen, especially when it is administered in combination with the conventional cyanide antidotes, sodium nitrite and sodium thiosulfate. Potency ratios, which were derived from the LD50 values, were compared in groups of mice premeclicated with sodium thiosulfate and/or sodium nitrite in air and in oxygen. These results indicate that the administration of oxygen alone provides only minimal protection. Oxygen enhances the protective effect of sodium thiosulfate to a minor degree, while not at all enhancing that of sodium nitrite; and yet, it strikingly potentiates the effectiveness of a combination of these two antagonists against cyanide intoxication.

Accepted on March 3, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.