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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 2, 367-372, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

CURARE-LIKE ACTIVITY OF POLYBUTYLENE GLYCOL ADDUCTS

Leslie P. McCarty 1 and Maynard B. Chenoweth 1

1 Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan

Polymers of butylene glycol R—(C4H8O)x—C4H8—R, where R is —NH(CH2)2NH(CH2)2NH2 or —N+(CH3)2(CH2)2N+-(CH3)2(CH2)2N+(CH3)3, are about as active as d-tubocurarine (d-TC) and, except for lack of effective antagonism by edrophonium, qualitatively similar to d-TC as well as to similar polymers of propylene glycol. Both classes of compounds are effective orally and cutaneously.

Accepted on February 17, 1966






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