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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 2, 361-366, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

PRE- AND POSTJUNCTIONAL EFFECTS OF DIPHENYLHYDANTOIN AT THE CAT SOLEUS NEUROMUSCULAR JUNCTION

Arthur Raines 1 and Frank G. Standaert 1

1 Department of Pharmacology, Cornell University Medical College, New York, New York

Diphenylhydantoin, in anticonvulsant doses, abolishes neural repetitive after-discharges originating in the nerve terminals of soleus motor axons of the cat. The suppression of these after-discharges markedly reduces posttetanic potentiation of the soleus muscle. Diphenylhydantoin modifies the tetanic contraction and often increases twitch tension by a direct effect on muscle. The suppression of high-frequency neural repetitive after-discharges may be one aspect of the anticonvulsant action of this drug.

Accepted on February 25, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.