RENAL EFFECTS OF EXOGENOUS ADENOSINE DERIVATIVES IN THE CHICKEN

¹ Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

Renal effects of exogenous adenosine, adenosine-5'-monophosphate (AMP), adenosine-5'-diphosphate (ADP), adenosine-5'-triphosphate (TP) and inosine triphosphate (TP) were examined in the Sperber chicken preparation. Upon u unilateral infusion into the renal portal system, at the rate of 0.04 µmol/min, all of the compounds, except ITP, were equipotent in reduction of urine flow, Na⁺, Cl^- and K⁺ excretion from the ipsilateral kidney. The antidiuretic actions of adenosine and AMP were correlated with simultaneous reduction in inulin excretion. There was no statistically significant change in p-aminohippuric acid (PAH) excretion. Following ADP or ATP, there was no statistically significant change in either inulin or PAH excretion. Since, on the average, 344 Na⁺ were reabsorbed for each ATP infused, the effect could not have been due to a simple addition of energy. It was estimated that most of the infused ATP was not significantly hydrolyzed in blood in transit to the peritubular area. ITP did not change any of the functions measured.