ON THE PHARMACOLOGY OF 2-(1-PIPERAZINYL)QUINOLINE

¹ Instituto Miles de Terapéutica Experimental, México, D.F., México
² Instituto Miles de Terapéutica Experimental, México, D. F., México

A study was made of the pharmacology of 2-(1-piperazinyl)-quinoline with special attention to its action on diverse smooth muscle preparations. The new compound was shown to be very potent in provoking contractions of uterine smooth muscle in vivo and in vitro. In assays on isolated rat uteri, it was more potent than methylergonovine. It also stimulated aorta, nictitating membrane, intestinal, tracheal and urinary bladder smooth muscle. However, these diverse preparations were much less sensitive to the compound than was the uterine smooth muscle. The drug did not apparently act on adrenergic receptor sites. It seemed possible that serotonin-sensitive structures could be involved in the uterine actions. At doses about 1000 times those required to demonstrate action on the uterus, piperazinylquinoline produced an interesting type of central nervous system stimulation, with recurrent behavioral alterations.