EFFECTS OF THE INSECTICIDE ENDRIN ON THE CARDIOVASCULAR SYSTEM OF THE DOG

¹ Veterans Administration Hospital, University of Oklahoma Medical Center, and Civil Aeromedical Research Institute, Oklahoma City, Oklahoma

Effects of the chlorinated hydrocarbon insecticide endrin on the cardiovascular system were studied. Experiments were carried out on anesthetized dogs administered endrin (3g/ g b. t. . .). A marked and progressive increase in venous return (cardiac output) occurred within 30 min following endrin administration. Total peripheral resistance fell significantly and remained low. No changes in pulmonary vascular resistance were observed. Endrin appeared to exert a toxic action on the left ventricle; left heart failure demonstrated by elevated left atrial pressure regularly occurred. Animals given endrin exhibited large increases in blood catecholamine concentration, which was significantly depressed when pH was maintained constant with a blood buffer. Adrenalectomy significantly decreased catecholamine concentrations which, however, were significantly elevated above preendrin values. Cardiovascular alterations were not significantly correlated with blood concentrations of catecholamines after endrin.

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