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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 2, 203-210, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

NORMAL AND ARRHYTHMIC BEATING IN ISOLATED CULTURED HEART CELLS AND THE EFFECTS OF DIGOXIN, QUINIDINE AND PROCAINE AMIDE

Edward N. Mercer 1 and Gordon E. Dower 1

1 Department of Pharmacology, University of British Columbia, Vancouver, Canada

Cultures of isolated chmick embryo heart cells were prepared by trypsin dissociation. The complete growth medium was a modified Puck's solution. Normal and arrhythmic beating in discrete cultivated chick embryo heart cells was quantified. Comparisons between atrial and ventricular cells revealed that the former beat in greater numbers, were more arrhythmic and contracted more briskly. The incidence of cellular arrhythmias was strikingly increased by digoxin. Both quinidine and procaine amide depressed beating, but neither caused reduction of digoxin-induced arrhythmias. The greatest proportion of arrhythmic cells occurred in atrial cells treated with digoxin and quinidine in combination.

Accepted on March 10, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.