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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 2, 197-202, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

CHRONOTROPIC ACTION OF AMINO ACIDS

Libi Sherf 1 and Thomas N. James 1

1 Section on Cardiovascular Research, Henry Ford Hospital, Detroit, Michigan

The chronotropic effect of 17 amino acids was studied by direct perfusion of the sinus node through its nutrient artery in vivo in the dog. Fourteen of the amino acids had no significant chronotropic effect; that of histidine was only weakly negative. Aspartic acid and glutamic acid both produced a negative chronotropic effect which appears to be due to a direct action on the sinus node, has no cholinergic or antiadrenergic component, and is not pH-dependent.

Accepted on March 4, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.