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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 1, 97-103, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF IPRONIAZID PHOSPHATE ON THE INTERMEDIARY METABOLISM OF GLUCOSE BY THE RABBIT HEART

Kenneth F. Tempero 1 and Gerald A. Kien 1

1 Department of Pharmacology, Northwestern University School of Medicine, Chicago, Illinois

The effect of iproniazid phosphate on the pattern of the flux of carbon from labeled glucose through intracellular glucose, lactic acid, alanine, malic acid, aspartic acid, glutamic acid and carbon dioxide was studied in the unanesthetized albino rabbit. Metabolites were separated and identified by means of ion exchange chromatography, and the flux of labeled carbon through the various intermediates of the Embden-Meyerhof and Krebs cycle pathways was followed via scintillation spectrometry. Iproniazid phosphate was found to decrease the flux of carbon from glucose through most of the intermediates studied. Galactose studies indicate that iproniazid does not adversely affect the ability of the myocardial cell membrane to transport glucose. The authors postulate a block in the Embden-Meyerhof pathway prior to the formation of pyruvate.

Accepted on February 2, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.