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*RESERPINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 1, 81-89, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF NOREPINEPHRINE ISOMERS ON VARIOUS SUPERSENSITIVITIES OF THE CAT NICTITATING MEMBRANE

R. J. Seidehamel 1, P. N. Patil 1, A. Tye 1, and J. B. LaPidus 1

1 College of Pharmacy, The Ohio State University, Columbus, Ohio

Superesensitivity of the cat nictitating membrane produced by chronicpretreatment with reserpine, decentralization or denervation was investigated to determine possible stereospecificity between D(-)- and L(+)-norepinephrine. Nictitating membrane contractions of spinal cats in response to isomers (intravenously injected) were magnified and recorded on a drum with an isotonic lever system. The degree of sensitization was determined by measuring horizontal shifts of dose-response curves for sensitized preparations to the left of their controls at the ED20 mm level. Supersensitivity caused by chronic pretreatment with reserpine or denervation is stereospecific for D(-)-as against L(+)- norepinephrine. However, after acute pretreatment of the preparations with reserpine, decentralization but not denervation supersensitivity is stereospccific in the same manner.

Accepted on January 17, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.