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Journal of Pharmacology And Experimental Therapeutics, Vol. 153, Issue 1, 159-166, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE PHARMACOKINETICS OF SALICYLATE ELIMINATION IN MAN AND RATS

Eino Nelson 1, Manabu Hanano 1, and Gerhard Levy 1

1 Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

The rat, like man, has only limited capacity for the synthesis of salicylurate from salicylate and glycine. The administration of glycine has no effect on the metabolism of salicylate in man and rats or on the toxicity of salicylate in rats. Pharmacokinetic constants for salicylurate formation are in good agreement with apparent in vivo Km and Vmax values obtained from appropriate Lineweaver-Burk plots. In vivo Km values are the same in man and rats, but Vmax is about 4 times higher in man, on a body weight basis, than in rats.

Accepted on February 2, 1966






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.