THE RENAL EXCRETION OF ETHYLENEDIAMINETETRAACETATE IN THE DOG

¹ Department of Medicine, University of Chicago School of Medicine, Chicago, Illinois

The renal excretion of calcium-ethylenediaminetetraacetic acid (EDTA) has been studied in 38 dogs by means of clearance techniques and competitive and selective tubular transport inhibition. In 60 periods, the renal clearance of EDTA closely approximated the inulin clearance with an EDTA/inulin clearance ratio of 1.02 ± 0.07. Probenecid, N'- methylnicotinamide and cyanine 863 had no specific inhibitory effect on the renal clearance of EDTA. Neither urinary acidification, alkalinization nor increasing urine flow attributa- ble to a solute diuresis appreciably influenced its excretion. EDTA appears to be excreted by glomerular filtration independent of the primary secretory pathways of acidic or basic compounds and without significant reabsorption. Determination of EDTA clearance represents an additional means of measuring glomerular filtration rate in the dog.