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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 3, 469-477, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF DESMETHYLIMIPRAMINE ON UPTAKE OF dl-NOREPINEPHRINE-7-H3 IN THE HEART

Elwood O. Titus 1, Norbert Matussek 1, Herbert E. Spiegel 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Desmethylimipramine (DMI) inhibits uptake of dl-norepinephrine-7-H3 in cat heart slices and in the mouse heart in vivo, but does not deplete previously established stores of labeled norepinephrine in the mouse heart. Although the dose of reserpine that is equivalent to 10 mg of DMI per kg in its effect on uptake is small (0.1 mg/kg), reserpine at this level retains its ability to deplete. The depleting effects of small doses of reserpine are inhibited by DMI. These and other observations suggest that DMI acts at a site in the membrane which is probably a part of the system for the uptake of norepinephrine and which has some affinity for a variety of amines.

Accepted on December 16, 1965






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.