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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 3, 397-416, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

ACTTONS OF ACETYLCHOLINE ON MAMMALIAN MOTOR NERVE TERMINAL

Walter F. Riker Jr. 1

1 Department of Pharmacology, Cornell University Medical College, New York, New York

The experiments described herein indicate that the actions of exogenous acetylcholine (ACh) on the neuromuscular junction are complex. It was learned that ACh has three distinct types of action on soleus motor nerve terminal. New light is shed on the junctional depolarizing action in that motor nerve terminal susceptibility in vivo is recognized. Also, a definite but limited facilitatory action and a long lasting depressant action of ACh have been located to the motor nerve terminal. These actions, and the motor nerve terminal as their site, provide a suitable explanation for the seven different neuromuscular effects of ACh observed in these experiments. Since there is no firm evidence in behalf of a special reactivity of the subneural muscle structure to ACh, it may well be that the proclaimed sensitivity of neuromuscular junction to ACh is attributable to the susceptibility of motor nerve terminal to the ion. Furthermore, the results do not offer any certain grounds for assigning to ACh a physiologic role in neuromuscular transmission.

Accepted on January 7, 1966




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.