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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 2, 354-361, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics


DIFFERENTIAL EFFECTS OF TWO PHENOTHIAZINES ON CHAIN AND TANDEM SCHEDULE PERFORMANCE

John R. Thomas 1

1 Institute for Behavioral Research, Silver Spring, Maryland

The effects of chiorpromazine and trifluoperazine on the behavior of pigeons trained to respond on a multiple (fixed ratio chain) (fixed ratio tandem) schedule of reinforcement were studied. The behavioral effects differentiating the two drugs occurred most clearly in the first component of the chained schedule. Differentiation of drug effects was not as clear for the other components. Chlorpromazine increased response rate in the first chain component relatively more than it increased the rate in the first tandem component. Trifluoperazine decreased response rate in the first chain component relatively more than it decreased the rate in the first tandem component.

Accepted on November 22, 1965







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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.