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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 2, 293-297, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DISULFIRAM ON THE RESTORATION OF THE RESPONSE TO TYRAMINE BY DOPAMINE AND agr-METHYLDOPA IN THE RESERPINE-TREATED CAT

Jose M. Musacchio 1, B. Bhagat 1, C. J. Jackson 1, and Irwin J. Kopin 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, Howard University, Washington, D.C.

Inhibition of dopamine-beta- oxidase with disulfiram prevents the restoration by dopamine and agr-methyldopa of the response to tyramine in reserpine-treated animals. Disulfiram does not prevent the restoration of the actions of tyramine by norepinephrine and does not interfere with the actions of large doses of tyramine in normal animals. These results suggest that beta-hydroxylation of dopamine and agr-methyldopamine is necessary for restoration of the response to tyramine in reserpine-treated animals.

Accepted on November 3, 1965






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.