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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 2, 265-274, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE CARDIOVASCULAR PHARMACOLOGY OF LIDOFLAZINE, A LONG-ACTING CORONARY VASODILATOR

Wolfgang K. A. Schaper 1, Raymond Xhonneux 1, Anton H. M. Jageneau 1, and Paul A. J. Janssen 1

1 Janssen Pharmaceutica n. v., Research Laboratoria, Beerse, Belgium

A series of cardiovascular experiments with lidoflazine (R 7904) in anesthetized and unanesthetized dogs is described in detail. The results indicate that lidoflazine is a specific, orally active and very long-acting coronary vasodilating agent. It acts directly on the smooth muscles of the coronary vessels. Lidoflazine is chemically unrelated to the known coronary vasodilators.

Accepted on November 22, 1965




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.