HYPOTENSIVE ACTIVITY OF -HEPTAMETHYLENIMINOETHYLAMINOGUANIDINE SULFATE

¹ Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania

- Heptamethyleniminoethylaminoguanidine sulfate, EX 4891A, has been shown to be a potent hypotensive agent in the anesthetized rat, cat and dog and in the unanesthetized renal hypertensive dog. This compound was found to have a short-term direct vasodilator effect in the denervated hind limb of the dog. Interference with sympathetic neuronal activity was found in both the in vivo nictitating membrane-superior cervical ganglion preparation in cats and the in vitro isolated innervated rabbit ileum preparation. Cross-circulation studies in dogs indicated a lack of a centrally mediated hypotensive effect. EX 4891A depleted catecholamines from the rat ventricle but did not exhibit a sympathomimetic effect due to an acute release of catecholamines in active forms.