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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 1, 56-61, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF DOPAMINE-beta-HYDROXYLASE BY DISULFIRAM IN VIVO

J. M. Musacchio 1, M. Goldstein 1, B. Anagnoste 1, G. Poch 1, and I. J. Kopin 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, United States Public Health Service, Bethesda, Maryland, and Department of Psychiatry and Neurology, Neurochemistry Laboivztories, New York University School of Medicine, New York, New York

Disulfiram is a potent inhibitor of dopamine-beta-oxidase which lowers norepinephrine content of the tissues. It prevents conversion of dopamine-H3, tyramine-H3 and other phenylethylamines to their beta-hydroxylated derivatives, and presumably interferes with endogenous norepinephrine synthesis. The findings reported support the view that the diminished norepinephrine level in tissues following disulfiram treatment is a consequence of inhibition of dopamine-beta-hydroxylase. The results suggest that beta-hydroxylation can be made ratelimiting in catecholamine synthesis, even though it may not be the rate-limiting step under physiologic conditions.

Accepted on November 3, 1965




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Science, January 17, 1969; 163(3864): 299 - 301.
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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.