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Journal of Pharmacology And Experimental Therapeutics, Vol. 152, Issue 1, 151-156, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF DRUGS AND CARCINOGENS BY HUMAN LIVER ENZYMES

R. Kuntzman 1, L. C. Mark 1, L. Brand 1, M. Jacobson 1, W. Levin 1, and A. H. Conney 1

1 The Wellcome Research Laboratories, Tuckahoe, New York, and the Department of Anesthesia, Columbia University, New York, New York

Human liver contains enzyme systems which catalyze the ring hydroxylation of 3,4-benzpyrene, the side chain oxidation of pentobarbital, the O-dealkylation of acetophenetidin and the N-dealkylation of 3-methyl-4-monomethylaminoazobenzene. The rate of metabolism of these substrates by hepatic enzymes was compared in man and rat. The enzyme system which hydroxylates 3,4-benzpyrene was studied in detail. This enzyme system in man is similar to that found in the rat; both are localized in the microsomal fraction and require reduced triphosphopyridine nucleotide (NADPH) for activity. Methods are described for measuring oxidative microsomal enzyme activity in small samples of human liver.

Accepted on October 20, 1965




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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.