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Journal of Pharmacology And Experimental Therapeutics, Vol. 151, Issue 2, 236-241, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

DEPLETION OF CARDIAC NOREPINEPHRINE IN THE MOUSE AND CAT BY MERCAPTOETHYLGUANIDINE

Victor Distefano 1 and Janet J. Klahn 1

1 Department of Pharmacology, University of Rochester School of Medicine, Rochester, New York

Mercaptoethylguanidine (MEG) lowers norepinephrine (NE) levels in the hearts of mice and cats. Brain norepinephrine is unaffected. The ganglionic blocking agent hexamethonium raises norepinephrine levels in cat heart, suggesting that the norepinephrine-depleting properties of mercaptoethylguanidine are not the result of its ganglionic blocking properties. Mercaptoethylguanidine lowers norepinephrine levels in isolated cat atria, constituting further evidence for a direct depleting effect.

Accepted on September 14, 1965




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