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Journal of Pharmacology And Experimental Therapeutics, Vol. 151, Issue 1, 55-58, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

STIMULATION OF THE RELEASE OF CATECHOLAMINES FROM ISOLATED ADRENAL GLANDS BY TYRAMINE

Robert L. Robinson 1

1 Department of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia

The injection of tyramine into the medium perfusing isolated dog adrenal glands produced an immediate increase in the rate of secretion of catecholamines. The response was dose-dependent. The ratio of epinephrine to norepinephrine in the effluent during the response to tyramine was not significantly different from that during spontaneous secretion. The intravenous injection of tyramine into anesthetized intact dogs caused a marked increase in mean blood pressure and a decrease in the catecholamine content of adrenal venous blood.

Accepted on August 3, 1965






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.