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Journal of Pharmacology And Experimental Therapeutics, Vol. 151, Issue 1, 139-142, 1966
Copyright © 1966 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF STEROIDS ON DRUG METABOLISM IN THE MOUSE

William J. Novick Jr. 1, Carl M. Stohler 1, and James Swagzdis 1

1 Smith Kline & French Laboratories, Philadelphia, Pennsylvania

Subcutaneous administration of several 19-nortestosterone derivatives produced an increased hepatic microsomal metabolism of hexobarbital and decreased zoxazolamine prostration time in mice. Testosterone and methyltestosterone produced an increased hexobarbital sleep time and testosterone decreased the rate of hepatic microsomal metabolism of hexobarbital. Although the ability of norethandrolone and SK & F 6612 (4-chloro-17agr-methyl-19-nortestosterone) to shorten hexobarbital sleep time occurs within 6 to 12 hr after a single dose in mice, this effect of testosterone derivatives in rats occurs only after prolonged treatment.

Accepted on August 26, 1965






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics.