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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 3, 469-475, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

SELECTIVITY OF ESTROGEN DISTRIBUTION IN TISSUES

Arnold J. Eisenfeld 1 and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

Circulating estradiol is selectively accumulated by the anterior pituitary, uterus, vagina, hypothalamus, septum and preoptic region. Pretreatment with the progestin norethynodrel reduced the H3-estradiol concentrations in the anterior pituitary, uterus, vagina, heart, adrenal, hypothalamus, preoptic region and septum. Treatment with norethynodrel after H3-estradiol administration reduced the radioactive concentration only in the uterus and vagina. Norethynodrel appeared to function as a competitive inhibitor of estradiol for binding. Evidence has been presented for an estradiol saturable binding mechanism in the anterior pituitary, uterus, vagina, and hypothalamus.

Accepted on July 23, 1965




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D. W. Pfaff
Autoradiographic Localization of Radioactivity in Rat Brain after Injection of Tritiated Sex Hormones
Science, September 27, 1968; 161(3848): 1355 - 1356.
[Abstract] [PDF]


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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.